Clinical Trial

"Considerations for development of an evidence dossier to support the use ofmobile sensor technology for clinical outcome assessments in clinical trials"

Type: 
Journal
Year: 
2020
Authors: 
M.K. Walton, J.C. Cappelleri, B. Byrom, J.C. Goldsack, S. Eremenco, D. Harris, E. Potero, N.Patel, E. Flood, M. Daumer

AVAPed study - Cerebral Palsy and Mobility (DLR Cologne and SLC - The Human Motion Institute)

Start: 
03/2018
End: 
10/2018

Acceptance and Validity of 3- Acceleronetric Gait Analysis in Pediatric Patients

„Mobile Accelerometry in Clinical Trials: Potential Applications and Meaningful Outcomes”, DIA 2018 Workshop

Type: 
Contribution to Conference
Year: 
2018
Authors: 
Daumer M
This interactive workshop seeks to continue the recent discussions
on wearables and patient-focused outcomes in clinical trials. We will
discuss the applicability and suitability of mobile sensor technology to
various types of studies and the relevance of sensor-derived outcomes
to clinical decision-making. Physical activity, in particular walking,
plays a major role as a potential patient-oriented, sensor-derived
outcome measure in a broad range of diseases. Valid and reliable methods
to assess physical activity are currently developed and/or refined. One

“Continuous Monitoring of Patient Mobility for 18 Months Using Inertial Sensors following Traumatic Knee Injury: A Case Study”, Digit Biomark 2018;2:79–89, doi.org/10.1159/000490919

Type: 
Journal
Year: 
2018
Authors: 
Mueller A, Hoefling H, Nuritdinow T, Holway N, Schieker M, Daumer M, Clay I

Continuous patient activity monitoring during rehabilitation, enabled by digital technologies,
will allow the objective capture of real-world mobility and aligning treatment to each
individual’s recovery trajectory in real time. To explore the feasibility and added value of such
approaches, we present a case study of a 36-year-old male participant monitored continuously
for activity levels and gait parameters using a waist-worn inertial sensor following a
tibial plateau fracture on the right side, sustained as a result of a high-energy trauma during

" POSTOPERATIVE MOBILITY OF TRAUMATIZED GERIATRIC PATIENTS: A PILOT STUDY USING ACTIBELT TECHNOLOGY", Orthopaedic Proceedings, Volume 100-B, Issue SUPP_14 / November 2018

Type: 
Journal
Year: 
2018
Authors: 
Nuritdinow T, Holzschuh J, Keppler A, Lederer C, Boecker W, Kammerlander C, Daumer M, Fuermetz J

Capturing objective data of the postoperative changes in the mobility of
patients is expected to generate a better understanding of the effect
of postoperative treatment. Until recently, the collection of
gait-related data was limited to controlled clinical environments. The
emergence of accurate wearable accelerometers with sufficient runtime,
however, enables the long-term measurement and extraction of mobility
parameters, such as “real-world walking speed”. An interim analysis of
1967 hours of actibelt data (3D accelerometer, 100 Hz) from 5 patients

"Low clinical conversion rate in clinically isolated syndromes (CIS) patients – diagnostic benefit of McDonald 2010 criteria?", Eur J Neurol. 2017, ID: ENE13476, DOI: 10.1111/ene.13476

Type: 
Journal
Year: 
2017
Authors: 
Rosenkranz S, Kaulen B, Neuhaus A, Siemonsen S, Koepke S, Daumer M, Stellmann JP

BACKGROUND AND PURPOSE:

New diagnostic criteria of multiple
sclerosis (MS) increase the number of patients being diagnosed with MS
whilst a substantial part might not convert to clinically definite MS
(CDMS). The diagnostic accuracy of the McDonald 2005 and 2010 criteria
for conversion to CDMS was evaluated in an unselected cohort of patients
in whom an MS diagnostic work-up was decided.

The BEGIN Study: Assessment of physical activity, fatigue and health-related quality of life in the early stages of multiple sclerosis

Type: 
Contribution to Conference
Year: 
2007
Authors: 
M., Hagstromer M., Wicklein EM., Daumer M., Penner IK., Sjostrom M.: ECTRIMS 2007, Prague, Multiple Sclerosis, 2007 Oct; 13 Supplement 2, P867, S263

Analysis of long-term clinical outcome in MS – a longitudinal approach

Type: 
Contribution to Conference
Year: 
2009
Authors: 
Neuhaus A, Strobl R, Daumer M, Scalfari A, Muraro P, Ebers G: accepted as Poster for ECTRIMS
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