"Low clinical conversion rate in clinically isolated syndromes (CIS) patients – diagnostic benefit of McDonald 2010 criteria?", Eur J Neurol. 2017, ID: ENE13476, DOI: 10.1111/ene.13476

Type: 
Journal
Year: 
2017
Authors: 
Rosenkranz S, Kaulen B, Neuhaus A, Siemonsen S, Koepke S, Daumer M, Stellmann JP

BACKGROUND AND PURPOSE:

New diagnostic criteria of multiple
sclerosis (MS) increase the number of patients being diagnosed with MS
whilst a substantial part might not convert to clinically definite MS
(CDMS). The diagnostic accuracy of the McDonald 2005 and 2010 criteria
for conversion to CDMS was evaluated in an unselected cohort of patients
in whom an MS diagnostic work-up was decided.

METHODS:

Clinical,
magnetic resonance imaging and cerebrospinal fluid data were analysed
for all patients who presented with symptoms suspicious for MS at the
university based MS outpatient clinic between 2006 and 2010 (n = 165).

RESULTS:

Follow-up
was available for 131 patients. During the mean follow-up period of 2
years, 19% of patients developed CDMS whereas 64% of the patients
fulfilling McDonald 2010 criteria did not convert to CDMS.

CONCLUSION:

The
low clinical conversion rate indicates that the new diagnostic criteria
may increase the incidence of MS cases with a less active disease
course.